Haemophilus influenzae type b vaccine targets which serotype?

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Prepare for the Clinical Laboratory Science Bacteriology Test. Engage with multiple choice questions and flashcards with helpful hints and explanations. Ace your exam confidently!

Multiple Choice

Haemophilus influenzae type b vaccine targets which serotype?

Explanation:
The vaccine is designed against the capsule of Haemophilus influenzae type b. This bacterium has several capsule types, but the type b capsule (polyribosylribitol phosphate, PRP) is the one most associated with invasive disease in children. The Hib vaccine is a conjugate that links the PRP capsule to a protein carrier to provoke a strong, T‑dependent immune response in infancy, providing protection against serious Hib infections like meningitis and epiglottitis. It does not target non-encapsulated strains or other serotypes that lack the type b capsule.

The vaccine is designed against the capsule of Haemophilus influenzae type b. This bacterium has several capsule types, but the type b capsule (polyribosylribitol phosphate, PRP) is the one most associated with invasive disease in children. The Hib vaccine is a conjugate that links the PRP capsule to a protein carrier to provoke a strong, T‑dependent immune response in infancy, providing protection against serious Hib infections like meningitis and epiglottitis. It does not target non-encapsulated strains or other serotypes that lack the type b capsule.

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