Which Mycoplasmataceae has not been connected with human genital infections?

• A. Mycoplasma genitalium
• B. Ureaplasma urealyticum
• C. Mycoplasma pneumoniae
• D. Mycoplasma hominis

Answer: (C)

Tissue tropism within the Mycoplasmataceae distinguishes species that inhabit the genital tract from those that target the respiratory tract. Mycoplasma pneumoniae is a classic respiratory pathogen, primarily causing atypical pneumonia and other upper respiratory infections, and it is not typically linked to genital infections. In contrast, the other species—Mycoplasma genitalium, Ureaplasma urealyticum, and Mycoplasma hominis—are well documented to colonize the genitourinary tract and are associated with infections such as nongonococcal urethritis and pelvic inflammatory disease. So, the organism not connected with human genital infections is Mycoplasma pneumoniae.